Surgical Interventions, Malignancies, and Causes of Death in a FAP Patient Registry
| Autor: | Thomas Bartley Pickron, Deborah W. Neklason, Megan Keener, Austin R Cannon |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
business.industry Colorectal cancer Medical record Gastroenterology Cancer medicine.disease digestive system diseases Colorectal surgery Familial adenomatous polyposis 03 medical and health sciences 0302 clinical medicine Dysplasia 030220 oncology & carcinogenesis Internal medicine medicine 030211 gastroenterology & hepatology Surgery Gastrointestinal cancer business Cause of death |
| Zdroj: | Journal of Gastrointestinal Surgery. 25:452-456 |
| ISSN: | 1873-4626 1091-255X |
| DOI: | 10.1007/s11605-019-04412-9 |
| Popis: | Familial adenomatous polyposis (FAP) patients are at risk for numerous malignancies. Multiple surgeries exist to mitigate the risk of colorectal cancer. Surgeons must weigh future quality of life versus the risk of dysplasia. As FAP patient longevity increases, there remains a risk of other malignancies. This study examines surgical interventions, development of cancers, and causes of mortality in a FAP registry. Patients with FAP or attenuated FAP (aFAP) were identified by linking the Hereditary Gastrointestinal Cancer Registry with University of Utah’s medical records. Patients without sufficient information were excluded. Patient demographics, surgical histories, cancer diagnoses, and causes of death were extracted. Logrank and Fisher’s exact tests were employed to detect significant differences between groups. After exclusion criteria, 140 patients were analyzed. Sixty patients (42.9%) underwent total proctocolectomy with ileal pouch-anal anastomosis (IPAA) followed by 50 (35.7%) having total colectomy with ileorectal anastomosis (IRA). IPAA patients were more likely female (p = 0.01) and have FAP (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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