The type II anti-diabetic activity of an Aloe formulation in DIO mice (B80)
| Autor: | Kyungjae Kim, Kwanghee Kim, Hyunyul Kim, Jeunghak Kwon, Shinha Han, Chong-Kil Lee |
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| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 178:LB17-LB17 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.178.supp.b80 |
| Popis: | Aloe is known to have various medical effects. These include healing damaged skin, as well as anti-diabetic, anti-cancer, and anti-arthritis activity. This study evaluated the anti-hyperglycemic effect of an Aloe formulation in DIO (Diet induced obesity) mice. The aloe formulation (AF) reduced body weight gain, fasting blood glucose, plasma triglyceride, the size of fat cells, and the amount of neutral fat deposits in the liver and improved insulin action. The AF treated group showed a reduction in the size of epididymal fat cells compared with the untreated group, and a lower amount of neutral fat deposits in the liver. AF exerted beneficial effects on lipogenesis related genes, such as SREBP1a, FAS, GPAT, and SCD-1 expressions in liver. These results suggest that AF is useful as an anti-diabetic treatment for Type II diabetes patients. |
| Databáze: | OpenAIRE |
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