Electrochemical aptasensor based on a potassium ion-triggered DNA conformation transition and self-assembly on an electrode
| Autor: | Fanyu Meng, Hua Chai, Xiaoyi Ma, Qian Mei, Yuguo Tang, Peng Miao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Chemistry
Hybridization probe Aptamer Potassium chemistry.chemical_element 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Electrochemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound Electrode Materials Chemistry A-DNA Self-assembly 0210 nano-technology DNA |
| Zdroj: | New Journal of Chemistry. 43:7928-7931 |
| ISSN: | 1369-9261 1144-0546 |
| Popis: | Herein, a novel electrochemical biosensor for the sensitive and selective detection of potassium ions (K+) was developed. An aptamer sequence against K+ was integrated into a DNA probe for specific recognition, which initiates a DNA conformation transition and activates a thiol group for the effective self-assembly of the DNA probe on a gold electrode surface. By analyzing the electrochemical signals labelled on the DNA probe, the K+ level can be facilely determined. The proposed electrochemical aptasensor is based on a simple sensing principle and straightforward operation. Moreover, excellent analytical performances were achieved owing to the ingenious design, which may inspire the development of additional electrochemical biosensors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|