First in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography
| Autor: | Klaus-Peter Stein, I. E. Sandalcioglu, Belal Neyazi, Karl Hartmann |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pharmacology genetic structures Pia mater medicine.diagnostic_test business.industry medicine.medical_treatment Brain cortex 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Neurology Neuroimaging Optical coherence tomography In vivo Arachnoid mater medicine Neurology (clinical) Subarachnoid space business 030217 neurology & neurosurgery Craniotomy Biomedical engineering |
| Zdroj: | Therapeutic Advances in Neurological Disorders. 12:175628641984304 |
| ISSN: | 1756-2864 |
| Popis: | The present work explores optical coherence tomography (OCT) as a suitable in vivo neuroimaging modality of the subarachnoid space (SAS). Patients ( n = 26) with frontolateral craniotomy were recruited. The temporal and frontal arachnoid mater and adjacent anatomical structures were scanned using microscope-integrated three-dimensional OCT, (iOCT). Analysis revealed a detailed depiction of the SAS (76.9%) with delineation of the internal microanatomical structures such as the arachnoid barrier cell membrane (ABCM; 96.2%), trabecular system (50.2%), internal blood vessels (96.2%), pia mater (26.9%) and the brain cortex (96.2%). Orthogonal distance measuring was possible. The SAS showed a mean depth of 570 µm frontotemporal. The ABCM showed a mean depth of 74 µm frontotemporal. These results indicate that OCT provides a dynamic, non-invasive tool for real-time imaging of the SAS and adjacent anatomical structures at micrometer spatial resolution. Further studies are necessary to evaluate the value of OCT during microsurgical procedures. |
| Databáze: | OpenAIRE |
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