| Autor: |
Clive Hawkins, E. P. G. H. du Boulay, A. Brar, Tamas Revesz, Steven Williams, GJ Barker, J. Newcombe, W. I. McDonald, D. G. MacManus, BD Youl |
| Rok vydání: |
1991 |
| Předmět: |
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| Zdroj: |
Proceedings of the XIV Symposium Neuroradiologicum ISBN: 9783642493317 |
| DOI: |
10.1007/978-3-642-49329-4_144 |
| Popis: |
Lipid imaging has been used to study the multiple sclerosis (MS) lesion both in vivo and in vitro. With echo difference imaging (EDI) to detect free lipid, regions of high signal were seen at the periphery of lesions in post-mortem brain slices, and these corresponded histologically with the presence of neutral lipid derived from myelin breakdown in regions of active inflammation. In vivo, regions of high signal on EDI were also seen in MS lesions, and were associated with blood-brain barrier breakdown and inflammation as assessed by gadolinium-DTPA enhancement. NMR spectra from unfixed MS spinal cord suggest that the abnormal EDI signal originates from methylene and methyl protons in the lipids. Thus, it is now possible to detect the two major destructive processes in the MS lesion, demyelination and inflammation. Lipid imaging promises to be useful in monitoring the time course of demyelination and its modification by treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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