Dairy Fat Intake, Plasma Pentadecanoic Acid, and Plasma Iso-heptadecanoic Acid Are Inversely Associated With Liver Fat in Children
| Autor: | Cynthia Knott, Michael S. Middleton, Elizabeth L. Yu, Martina Wallace, Claude B. Sirlin, Bruce A. Barshop, Jon A. Gangoiti, Nidhi Goyal, Mary Catherine Sawh, Noah Meurs, Alexandra Schlein, Jeffrey B. Schwimmer, Jivani M. Gengatharan, Janis Durelle, Craig Bross, Christian M. Metallo, Emma Shapiro, Kimberly P. Newton |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Gastroenterology Plasma levels Pentadecanoic acid medicine.disease Branched chain fatty acids 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Fat intake chemistry 030225 pediatrics Internal medicine Pediatrics Perinatology and Child Health Liver fat Nonalcoholic fatty liver disease medicine 030211 gastroenterology & hepatology Heptadecanoic acid Steatosis business |
| Zdroj: | Journal of Pediatric Gastroenterology & Nutrition. 72:e90-e96 |
| ISSN: | 1536-4801 0277-2116 |
| DOI: | 10.1097/mpg.0000000000003040 |
| Popis: | Objectives We sought to evaluate the relevance of pediatric dairy fat recommendations for children at risk for nonalcoholic fatty liver disease (NAFLD) by studying the association between dairy fat intake and the amount of liver fat. The effects of dairy fat may be mediated by odd chain fatty acids (OCFA), such as pentadecanoic acid (C15:0), and monomethyl branched chain fatty acids (BCFA), such as iso-heptadecanoic acid (iso-C17:0). Therefore, we also evaluated the association between plasma levels of OCFA and BCFA with the amount of liver fat. Methods Observational, cross-sectional, community-based sample of 237 children ages 8 to 17. Dairy fat intake was assessed by 3 24-hour dietary recalls. Plasma fatty acids were measured by gas chromatography-mass spectrometry. Main outcome was hepatic steatosis measured by whole liver magnetic resonance imaging proton density fat fraction (MRI-PDFF). Results Median dairy fat intake was 10.6 grams/day (range 0.0--44.5 g/day). Median liver MRI-PDFF was 4.5% (range 0.9%-45.1%). Dairy fat intake was inversely correlated with liver MRI-PDFF (r = -0.162; P = .012). In multivariable log linear regression, plasma C15:0 and iso-C17:0 were inverse predictors of liver MRI-PDFF (B = -0.247, P = 0.048; and B = -0.234, P = 0.009). Conclusions Dairy fat intake, plasma C15:0, and plasma iso-C17:0 were inversely correlated with hepatic steatosis in children. These hypothesis-generating findings should be tested through clinical trials to better inform dietary guidelines. |
| Databáze: | OpenAIRE |
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