ChemInform Abstract: Nickel-Catalyzed Negishi Cross-Coupling of Bromodifluoroacetamides

Autor:	Masaaki Omote, Saori Shinohara, Akira Ando, Atsushi Tarui, Kazuyuki Sato
Rok vydání:	2016
Předmět:	Coupling chemistry.chemical_compound Nickel Chemistry Negishi coupling Ligand Aryl Reagent Amide chemistry.chemical_element General Medicine Combinatorial chemistry Catalysis
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201629062
Popis:	A nickel-catalyzed Negishi coupling of bromodifluoroacetamides with arylzinc reagents has been developed. This reaction allows access to difluoromethylated aromatic compounds containing a variety of aryl groups and amide moieties. Furthermore, highly effective transformation of the functionalized difluoromethyl group (−CF2CONR1R2) was realized via microwave-assisted reduction under mild conditions. The notable features of this strategy are its generality and its use of a low-cost nickel catalyst and ligand; thus, this reaction provides a facile method for applications in drug discovery and development.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d5c687da7ac2bd30defd5166cc867168 https://doi.org/10.1002/chin.201629062 Zobrazit plný text záznamu Plný text