FRI0483 Is There A Difference in Autoimmune Myopathies with and without Raynaud's Phenomenon? A Capillaroscopy Study

Autor: L. Petrariu, G. Strugariu, Cristina Pomirleanu, C. Belibou, Codrina Ancuta, R. Maxim
Rok vydání: 2016
Předmět:
Zdroj: Annals of the Rheumatic Diseases. 75:613.2-613
ISSN: 1468-2060
0003-4967
DOI: 10.1136/annrheumdis-2016-eular.4543
Popis: Background The autoimmune myopathies (IM) comprise a broad spectrum of acquired muscular disorders characterized by autoimmune damage of skeletal muscle and complex visceral involvement, leading to chronic dysfunction and disability. Objectives The aim of our study was to assess the association between Raynaud9s phenomenon (RP) and capillaroscopic findings in patients with polymyositis (PM), dermatomyositis (DM) and anti-synthetasic syndrome (ASS), and to identify possible correlation with clinical and serological pattern. Methods Nailfold videocapillaroscopy (Optilia 200x) was performed in a cohort of 27 patients diagnosed with IM, 12 with RP and 15 age-, sex-, and disease-duration-matched without RP, and 19 healthy controls. Total number of capillaries, enlarged and giant capillaries, ramified capillaries, haemorrhages, haemosyderin deposits were each scored by a semiquantitative assessment, while the disorganization of the vascular array and avascular area were scored as present/absent. Data about IM activity (Myositis Disease Activity Assessment Tool), severity (Myositis Damage Index) and physical function (Stanford HAQ) were also collected. Findings were analysed using linear and logistic regression, adjusted for age and sex (SPSS-19 software). Results Patients with IM were frequently abnormal, with significant lower capillary density, higher dimensions, enlarged capillaries, haemorrhages and haemosyderin deposits as compared with healthy controls (p 80% of cases reported RP as the first manifestation of their disease, with frequently nailfold capillary abnormalities as compared to non-RP patients (p In addition, a scleroderma-like capillaroscopy pattern was identified in RP-positive patients, either DM or ASS. On the other hand, either normal or nonspecific capillaroscopy findings were found in RP-negative and PM. Pulmonary involvement (p We found an association between the presence of either active or late scleroderma pattern, elevated serum CK and disease activity: capillary loss was significantly associated high muscle and global disease activity, as well (p Anti-Jo-1 and anti-PL12 antibodies were associated with reduced capillary density (p Conclusions RP is associated with particular capillaroscopic findings in different IM subsets, suggesting that prognostic relevance of RP in myositis should be evaluated. Significant changes in the capillary pattern reported in IM, particulary reduced density, size abnormalities, haemorrhages, indicating that nailfold videocapillaroscopy may be useful as an outcome measure of microvascular disease in IM Disclosure of Interest None declared
Databáze: OpenAIRE
Externí odkaz: