Synthesis of [phenyl-2-3H]-travoprost: isopropyl ester prodrug of a selective prostaglandin FP receptor agonist
| Autor: | Jesse A. May, Ernest U. Do, Robert Selliah, Judith Egan, Anura P. Dantanarayana, Karen S. Haggard |
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| Rok vydání: | 2001 |
| Předmět: |
Agonist
Chemistry medicine.drug_class Stereochemistry Organic Chemistry Prostaglandin Prodrug Biochemistry Chemical synthesis humanities Analytical Chemistry chemistry.chemical_compound Drug Discovery medicine Radiology Nuclear Medicine and imaging Tritium Triol Travoprost Spectroscopy Isopropyl medicine.drug |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 44:173-183 |
| ISSN: | 1099-1344 0362-4803 |
| DOI: | 10.1002/jlcr.441 |
| Popis: | A method for the preparation of tritium labeled travoprost, a new ocular hypotensive prostaglandin, is described. A highly selective catalytic deiodination has been identified which provides [phenyl-2-3H]-travoprost in a single synthetic step from 2′-iodo-travoprost. Copyright © 2001 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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