Impulsive choices in mice lacking imprinted Nesp55
| Autor: | Antonius Plagge, Katie Lewis, Trevor Humby, Claire L. Dent, Anthony Roger Isles, Reiner Fischer-Colbrie, Jon F. Wilkins, Lawrence Stephen Wilkinson |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
TPH2 Serotonergic 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Neurology chemistry Dopamine DNA methylation Genetics medicine Serotonin Epigenetics Neurotransmitter Psychology Genomic imprinting Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Genes, Brain and Behavior. 15:693-701 |
| ISSN: | 1601-1848 |
| DOI: | 10.1111/gbb.12316 |
| Popis: | Genomic imprinting is the process whereby germline epigenetic events lead to parent-of-origin specific monallelic expression of a number of key mammalian genes. The imprinted gene Nesp is expressed from the maternal allele only and encodes for Nesp55 protein. In the brain, Nesp55 is found predominately in discrete areas of the hypothalamus and midbrain. Previously, we have shown that loss of Nesp55 gives rise to alterations in novelty-related behaviour. Here, we extend these findings and demonstrate, using the Nespm/+ mouse model, that loss of Nesp55 leads to impulsive choices as measured by a delayed-reinforcement task, whereby Nespm/+ mice were less willing to wait for a delayed, larger reward, preferring instead to choose an immediate, smaller reward. These effects were highly specific as performance in another component of impulsive behaviour, the ability to stop a response once started as assayed in the stop-signal reaction time task, was equivalent to controls. We also showed changes in the serotonin system, a key neurotransmitter pathway mediating impulsive behaviour. First, we demonstrated that Nesp55 is co-localized with serotonin and then went on to show that in midbrain regions there were reductions in mRNA expression of the serotonin-specific genes Tph2 and Slc6a4, but not the dopamine-specific gene Th in Nespm/+ mice; suggesting an altered serotonergic system could contribute, in part, to the changes in impulsive behaviour. These data provide a novel mode of action for genomic imprinting in the brain and may have implications for pathological conditions characterized by maladaptive response control. |
| Databáze: | OpenAIRE |
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