Acrylic acid grafted gelatin/LDH based biocompatible hydrogel with pH-controllable release of vitamin B12
| Autor: | Jayashree Nath, Asfi Ahmed, Swapan Kumar Dolui, Anupam Chowdhury, Priyankamoni Saikia |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
food.ingredient
Nanocomposite Biocompatibility Chemistry technology industry and agriculture 020101 civil engineering Geology macromolecular substances 02 engineering and technology 021001 nanoscience & nanotechnology complex mixtures Gelatin Controlled release 0201 civil engineering chemistry.chemical_compound food Geochemistry and Petrology Self-healing hydrogels medicine Hydroxide Swelling medicine.symptom 0210 nano-technology Acrylic acid Nuclear chemistry |
| Zdroj: | Applied Clay Science. 190:105569 |
| ISSN: | 0169-1317 |
| Popis: | In this work, gelatin-g-poly(acrylic acid) based pH-sensitive nanocomposite hydrogels incorporated with Layered Double Hydroxide (LDH) were developed. Using various spectroscopic techniques such as FTIR, XRD, SEM, EDX and TEM, the polymeric hydrogels were characterized. FTIR confirmed grafting of partially neutralized Acrylic Acid (AAc) on the backbone of Gelatin. Incorporation of LDH fillers inside the hydrogel matrix was established from XRD data. Inclusion of LDH resulted wrinkled morphology of the surface of the hydrogel from the SEM images. Formation of nanocomposites were further evaluated by TEM analysis which displayed significant change in the TEM morphology of the nanocomposite hydrogel. Using DLS, particle size for LDH were determined further and was found to be around 100 nm. Swelling value of the hydrogel was around 34 g/g. Biocompatibility results showed enhanced blood compatibility for the hydrogels. The controlled release studies performed using the hydrogels demonstrated vitamin B12 was released in Artificial Gastric Fluid (AGF) and in Artificial Intestinal Fluid (AIF) in a controlled manner. The release study was carried out for 7 h each and was evaluated using UV–visible spectrophotometer. From the curves, the cumulative release in AGF and AIF was found to be 24% and 31%, respectively. |
| Databáze: | OpenAIRE |
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