Lipase-Catalyzed Enantioselective Reaction Based on Remote Recognition of the Stereogenic Carbon Atom Away from the Reaction Site

Autor:	Hazuki Nagai, Eisaku Mizuguchi, Hiroshi Uchida, Kazuo Achiwa
Rok vydání:	1994
Předmět:	Carbon atom biology Organic Chemistry Enantioselective synthesis chemistry.chemical_element Combinatorial chemistry Catalysis Stereocenter chemistry biology.protein Lipase Solvent effects Carbon Reaction site
Zdroj:	Journal of Synthetic Organic Chemistry, Japan. 52:638-648
ISSN:	1883-6526 0037-9980
Popis:	The synthetic method of optically active compound by using lipase-catalysis in organic solvent has been generally accepted recently. Because lipases possess especially broad substrate specificity and are commercially available. However, efficient substrates of lipase-catalyzed asymmetric reactions were limited to be the compounds whose stereogenic carbon atoms were in the neighborhood of the reaction site.This review describes our investigation on substrates of which stereogenic carbon atoms are remote from the reacting site, leading to lipase-catalyzed asymmetric synthesis of optically active synthetic drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d5a32adfeca7d651b4579520ae919d0a https://doi.org/10.5059/yukigoseikyokaishi.52.638 Zobrazit plný text záznamu