Abacavir/Lamivudine Versus Tenofovir DF/Emtricitabine as Part of Combination Regimens for Initial Treatment of HIV: Final Results
| Autor: | Belinda Ha, Camlin Tierney, Laurie Myers, Ann C. Collier, Karen T. Tashima, Margaret A. Fischl, James F. Rooney, Eric S. Daar, Nasreen C. Jahed, Awny Farajallah, Robert L. Murphy, Catherine Godfrey, Chakra Budhathoki, David Katzenstein, Judith Feinberg, William C. Woodward, Katie R. Mollan, Paul E. Sax |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Efavirenz business.industry Lamivudine Abacavir/Lamivudine Emtricitabine Gastroenterology Virology Atazanavir chemistry.chemical_compound Infectious Diseases chemistry Abacavir Internal medicine medicine Immunology and Allergy Ritonavir business human activities Viral load medicine.drug |
| Zdroj: | The Journal of Infectious Diseases. 204:1191-1201 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jir505 |
| Popis: | (See the editorial commentary by Hull and Montaner, on pages 1154–6.) Background. AIDS Clinical Trials Group A5202 compared blinded abacavir/lamivudine (ABC/3TC) to tenofovir DF/emtricitabine (TDF/FTC) with efavirenz (EFV) or atazanavir/ritonavir (ATV/r) in human immunodeficiency virus (HIV)-infected treatment-naive patients, stratified by screening HIV RNA (< or ≥105 copies/mL). Due to higher virologic failure with ABC/3TC in the high HIV RNA stratum, blinded treatment was stopped in this group, but study follow-up continued for all patients. Methods. Primary endpoints were times to virologic failure, regimen modification, and safety event. Results. In the low HIV RNA stratum, time to virologic failure was similar for ABC/3TC vs TDF/FTC with ATV/r (hazard ratio [HR] 1.25, 95% confidence interval [CI] 0.76, 2.05) or EFV (HR 1.23, 95% CI 0.77, 1.96), with significantly shorter times to regimen modification for ABC/3TC with EFV or ATV/r and to safety events with EFV. Prior to stopping blinded treatment in the high stratum, higher virologic failure rates were seen with ABC/3TC with EFV (HR 2.46, 95% CI 1.20, 5.05) or ATV/r (HR 2.22, 95% CI 1.19, 4.14). Conclusions. In the low HIV RNA stratum, times to virologic failure for ABC/3TC or TDF/FTC were not different with EFV or ATV/r. In the high stratum, virologic failure rate was significantly higher for ABC/3TC than for TDF/FTC when given with either EFV or ATV/r. |
| Databáze: | OpenAIRE |
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