Asymmetric total synthesis of natural pyrrolizidine alkaloid, (+)-alexine

Autor:	Hidemi Yoda, Hideaki Katoh, Kunihiko Takabe
Rok vydání:	2000
Předmět:	chemistry.chemical_compound Pyrrolizidine alkaloid chemistry Stereochemistry Alkaloid Organic Chemistry Drug Discovery Lactam Total synthesis Organic chemistry Glycosidase inhibitor Biochemistry Stereocenter
Zdroj:	Tetrahedron Letters. 41:7661-7665
ISSN:	0040-4039
Popis:	The total synthesis of the potent glycosidase inhibitor (+)-alexine with five contiguous stereogenic centres [(1 R ,2 R ,3 R ,7 S ,7 aS )-3-hydroxymethyl-1,2,7-trihydroxypyrrolizidine alkaloid] is described featuring the efficient and stereodefined novel elaboration of the functionalized homochiral lactam derived from 2,3,5-tri- O -benzyl-β- d -arabinofuranose.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d58ffaa911a7752b4ca31df498aa8fce https://doi.org/10.1016/s0040-4039(00)01314-9 Zobrazit plný text záznamu Full Text from ScienceDirect