The pituitary-thyroid axis and oxygen consumption parameters under the conditions of chronic cold exposure in the North
| Autor: | O. A. Ketkina, A. M. Kaneva, T. P. Loginova, Yu. G. Solonin, N. N. Potolitsyna, E. P. Bojko, A. Yu. Loginov, A. Yu. Lyudinina, T. I. Kochan, N. G. Varlamova, T. V. Eseva, V. D. Shadrina, V. G. Evdokimov, O. V. Rogachevskaya, Vakhnina Na |
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| Rok vydání: | 2008 |
| Předmět: |
endocrine system
medicine.medical_specialty Pituitary gland Physiology business.industry Metabolism Hypothermia Peripheral Pituitary thyroid axis Endocrinology medicine.anatomical_structure Physiology (medical) Internal medicine Negative feedback medicine Endocrine system medicine.symptom business Hormone |
| Zdroj: | Human Physiology. 34:215-220 |
| ISSN: | 1608-3164 0362-1197 |
| DOI: | 10.1134/s0362119708020126 |
| Popis: | The functional state of the pituitary-thyroid axis (PTA) and oxygen consumption were studied monthly during one year in a group of soldiers from northern European Russia daily staying outdoors for 6–10 h. It was shown that the chronic exposure to low temperatures on the human body was accompanied by activation of metabolism of thyroid hormones, which was evident from accumulation of their free forms. The irritant caused no tension of the central link of the endocrine system, and although the levels of thyroid hormones in the blood were reduced, the mechanism of negative feedback was not activated, which was evidenced by a stably low level of thyrotrophic hormone of the pituitary gland. At the same time, the rapid change in the duration of daytime influencing the central links of the neuroendocrine system resulted in unbalance of feedback mechanisms. The illumination factor under the conditions of chronic hypothermia proved to be a stronger irritant for the central link of the endocrine system than the signals transmitted by feedback mechanisms from the peripheral parts of the PTA. |
| Databáze: | OpenAIRE |
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