Modified LSA2-L2 treatment in 53 children with E-rosette-positive T- cell leukemia: results and prognostic factors (a Pediatric Oncology Group Study)
Autor: | MH Duncan, GB Humphrey, Margaret P. Sullivan, Paul G. Dyment, Tribhawan S. Vats, DJ Pullen, John M. Falletta, James M. Boyett, Kenneth A. Starling, Vita J. Land |
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Rok vydání: | 1982 |
Předmět: |
Pediatrics
medicine.medical_specialty business.industry Immunology T-cell leukemia Cell Biology Hematology medicine.disease Biochemistry Gastroenterology law.invention Lymphoma Clinical trial Regimen chemistry.chemical_compound Leukemia Pharmacotherapy Randomized controlled trial chemistry law Internal medicine Medicine Uric acid business |
Zdroj: | Blood. 60:1159-1168 |
ISSN: | 1528-0020 0006-4971 |
Popis: | In an attempt to improve the poor outlook for children with T-cell leukemia (T-ALL), the Southwest Oncology Group, Pediatric Division, used a modified LSA2-L2 multidrug regimen to treat 53 patients with E- rosette-positive T-ALL. This regimen was chosen because of its demonstrated efficacy in T-cell (mediastinal) non-Hodgkin's lymphoma. Complete remission (CR) rate was 88%. Range of follow-up for those patients remaining in CR is 24–49 mo (median 39 mo). Life table analysis estimates that 40% (SE 8.3%) of all patients who started induction therapy will remain failure-free at 3 yr. For patients achieving CR, 46% (SE 9%) are projected to remain in both marrow and extramedullary CR at 3 yr. Median failure-free duration was 13 mo, but only 1 patient has relapsed beyond 16 mo. Twenty-nine percent of initial relapses were isolated CNS relapses. The following presenting factors did not relate significantly to outcome: hemoglobin, platelet count, uric acid, race, and mediastinal mass. Age greater than 10 yr was a poor prognosis indicator only in the less than 50,000/microliter WBC group. Sex was not a significant factor after adjusting for WBC. WBC was the most important prognostic factor: 19% (SE 8%) of patients with WBC greater than 50,000/microliter are projected to remain failure- free at 3 yr as compared to 67% (SE 11%) of patients with WBC less than 50,000/microliter. Although the overall results are better than those previously reported for pediatric patients with T-ALL, the long-term failure-free rate remains low for patients presenting with greater than 50,000/microliter WBC. |
Databáze: | OpenAIRE |
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