| Popis: |
Correlation of the properties of biofilms of microorganisms and malignant tumors indicates the existence of a certain analogy between them, which allows us to explain the essential circumstances of the formation of drug resistance. Intercellular substance plays a significant role in the functioning of both types of cell groups. Both types are characterized by the formation and local accumulation of structurally damaged proteins and peptides. The regularity of their interaction with membrane’s phospholipid bilayer creates prerequisites for the formation of β-structured inclusions that are characterized by electrical conductivity. This leads to membrane depolarization and, as a result, to disruption of its barrier function. An increase in the permeability of the membrane contributes to the entry of external genetic material, the formation of mutated forms and the development of drug resistance. |
