Five-year follow-up study afterHelicobacter pylorieradication: Reinfection and peptic ulcer status
| Autor: | Shi Gang Ding, Zhi Wei Xia, Xue Biao Huang, Li Ya Zhou, Zu Yao Shen, Shang Zhi Zhong, Shi Zhi Cao, Zhu Jin, San Ren Lin, Li Xin Wang |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
education.field_of_study medicine.diagnostic_test biology business.industry Peptic Population Gastroenterology Rapid urease test Helicobacter pylori medicine.disease biology.organism_classification Placebo Endoscopy Peptic ulcer Internal medicine medicine business education Omeprazole medicine.drug |
| Zdroj: | Chinese Journal of Digestive Diseases. 4:45-48 |
| ISSN: | 1443-9611 |
| Popis: | OBJECTIVE: To investigate the prevalence of peptic ulcers and Helicobactor pylori reinfection 5 years after H. pylori eradication. METHODS: One thousand and six adults were randomly sampled from the general population in a high-incidence region of gastric cancer. Of these, 552 subjects were confirmed to be H. pylori-positive by using both the rapid urease test and the Warthin−Starry stain. All H. pylori-positive subjects were randomly divided into two groups: (i) the eradication group, who received 1 week of omeprazole-based triple therapy; and (ii) the control group, who received placebo tablets. Four weeks after the cessation of treatment, 13C-urea breath tests demonstrated that H. pylori had been successfully eradicated in 88.9% of patients in the eradication group, whereas 96.4% of patients remained H. pylori positive in the control group. Subjects in both groups were followed up using endoscopy at the end of the first and fifth year after treatment. The H. pylori infection status was determined by using the rapid urease test and Warthin−Starry staining. RESULTS: The response rates to endoscopy at the end of the first and fifth year were 89.3 and 83.11%, respectively. The prevalence of peptic ulcers in the eradication group and control group were 9.87 and 7.61% before treatment, 3.70 and 12.58% 1 year after treatment (P |
| Databáze: | OpenAIRE |
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