Thiourea derivatives containing 4-arylthiazoles and d -glucose moiety: design, synthesis, antimicrobial activity evaluation, and molecular docking/dynamics simulations
| Autor: | Nguyen Dinh Thanh, Pham Hong Lan, Do Son Hai, Hoang Huu Anh, Nguyen Thi Kim Giang, Hoang Thi Kim Van, Vu Ngoc Toan, Nguyen Minh Tri, Duong Ngoc Toan |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | RSC Medicinal Chemistry. |
| ISSN: | 2632-8682 |
| Popis: | Substituted thioureas with 1,3-thiazole and d-glucose were gained from 2-amino-1,3-thiazoles and glucopyranosyl isocyanate. They had antimicrobial activity, some inhibiting S. aureus DNA gyrase, DNA Topo IV, and dihydrofolate reductase. IFD, MM-GBSA and MD were performed. |
| Databáze: | OpenAIRE |
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