Nuclear magnetic resonance spectra and stereochemistry of 4-substituted flavans

Autor:	C.P. Lillya, M.A. Vickars, A. Hairwe, B.J. Bolger, E.M. Philbin, K.G. Marathe
Rok vydání:	1966
Předmět:	Coupling constant Stereochemistry Dihydropyran Organic Chemistry Ring (chemistry) Biochemistry Spectral line NMR spectra database chemistry.chemical_compound Nuclear magnetic resonance chemistry Drug Discovery Cyclohexanes Vicinal
Zdroj:	Tetrahedron. 22:621-628
ISSN:	0040-4020
DOI:	10.1016/0040-4020(66)80031-5
Popis:	The NMR spectra of the 4α and β-benzoyloxyflavans have been completely analyzed, and the relative configurations deduced from coupling constant values. A simplified method of deducting relative stereochemistry of 4-substituted flavans from NMR spectra has been applied to these and other derivatives. The same dependence of vicinal coupling constants on the configuration of electronegative groups as exists in chair cyclohexanes has been found in 4-substituted flavans and has been tentatively interpreted as indicating a half-chair conformation for the dihydropyran ring.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d54d469a27e63167652fc8095a896efd https://doi.org/10.1016/0040-4020(66)80031-5 Zobrazit plný text záznamu