α-Glucosidase inhibitory activity of mangiferin-loaded F127/PEG micellar system
| Autor: | Nágila M.P.S. Ricardo, Lillian Maria Uchoa Dutra Fechine, Gerlan Oliveira do Nascimento, Maria Teresa Salles Trevisan, Francisco W.A. Bezerra, Luzia Kalyne Almeida Moreira Leal, Anderson F. de Sousa, Karen P.S. Lopes, Maria Elenir Nobre Pinho Ribeiro, Hilmara Helia de Sousa Amaral |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
Chromatography Aqueous solution Mechanical Engineering 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences In vitro 0104 chemical sciences chemistry.chemical_compound chemistry Mechanics of Materials PEG ratio Drug delivery medicine General Materials Science Solubility 0210 nano-technology Mangiferin Cytotoxicity Acarbose medicine.drug |
| Zdroj: | Materials Letters. 255:126522 |
| ISSN: | 0167-577X |
| DOI: | 10.1016/j.matlet.2019.126522 |
| Popis: | Mangiferin-loaded F127/PEG micellar systems were evaluated regarding the effect of PEG addition at different molecular weights, where the system with best mangiferin solubility response (0.5 wt% of PEG in 1 wt% F127 aqueous solution) was chosen to be a potential drug delivery system (DDS), which solubilized 7.92 mg dL−1 of mangiferin. Subsequently, the chosen mangiferin-loaded DDS was evaluated in regard the inhibition of enzyme α-glucosidase, which showed a more effective inhibition, around 95.42%, when compared to the standard acarbose (92.59%) and to the free-form mangiferin (90.42%). The same micellar system was also evaluated for its cytotoxicity, where no significative values of LDH activity was observed. No study has been done yet with both mangiferin and DDSs regarding in vitro α-glucosidase inhibitory activity. This work proposes a “new” alternative towards diabetes treatment. |
| Databáze: | OpenAIRE |
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