An efficient synthesis of the benzhydrylpiperazine delta opioid agonist (+)-BW373U86

Autor:	Robert W. McNutt, Michael J. Bishop
Rok vydání:	1995
Předmět:	Tertiary amine Chemistry Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Delta opioid agonist Highly selective Biochemistry BW373U86 chemistry.chemical_compound Drug Discovery Molecular Medicine Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:1311-1314
ISSN:	0960-894X
DOI:	10.1016/0960-894x(95)00213-d
Popis:	A diastereoselective version of Katritzky's method for tertiary amine formation provides an efficient route to the highly selective, non-peptidal, delta opioid agonist (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl]-N,N-diethylbenzamide [(+)-BW373U86], 1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d53d7b1e6955322b9fe4aab273cf6cbf https://doi.org/10.1016/0960-894x(95)00213-d Zobrazit plný text záznamu Full Text from ScienceDirect