The Development of a Manufacturable Synthesis of LY213829

Autor:	James Densmore Copp, Douglas Patton Kjell, Stephen C. Stirm, Francis Orerenyo Ginah, and Marvin M. Hansen, Slattery Brian James
Rok vydání:	2000
Předmět:	chemistry.chemical_compound Rhodanine Chemistry Organic Chemistry Moiety Nanotechnology Physical and Theoretical Chemistry Ring (chemistry) Combinatorial chemistry
Zdroj:	Organic Process Research & Development. 4:295-297
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op990197j
Popis:	The development of a manufacturable synthesis of LY213829 (4-thiazolidinone-5-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl] methyl) is described. Rather than reduction to eliminate the thiocarbonyl from the rhodanine moiety, the new route utilizes a novel concurrent ring opening with ammonia and re-cyclization with formaldehyde. This change obviates a potentially problematic zinc solid waste stream.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d52ecc9bd957281a712c540eb094a520 https://doi.org/10.1021/op990197j Zobrazit plný text záznamu