Evaluation of SNAP cPL, Spec cPL, VetScan cPL Rapid Test, and Precision PSL Assays for the Diagnosis of Clinical Pancreatitis in Dogs
| Autor: | Alyssa M. Sullivant, Andrew J. Mackin, Robert W. Wills, Todd M. Archer, Kari V. Lunsford, K. Rosenthal, G.E. Pachtinger, John M. Thomason, Harry Cridge, A.G. MacLeod |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
General Veterinary medicine.diagnostic_test 040301 veterinary sciences business.industry Snap Complete blood count Spec# Physical examination 04 agricultural and veterinary sciences 030230 surgery PSL medicine.disease Gastroenterology 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Pancreatitis Patient group Prospective cohort study business computer computer.programming_language |
| Zdroj: | Journal of Veterinary Internal Medicine. 32:658-664 |
| ISSN: | 0891-6640 |
| Popis: | Background The sensitivity, specificity, and agreement of 4 diagnostic assays (SNAP canine pancreatic lipase (cPL), specific cPL (Spec cPL), VetScan cPL Rapid Test, and Precision PSL) for pancreatitis in dogs have not been directly compared. Hypothesis/objectives To determine the level of agreement among each of the 4 assays and a clinical suspicion score, level of agreement among the assays, and sensitivity and specificity of each assay in a clinically relevant patient group. Animals Fifty client-owned dogs with clinical signs of gastrointestinal disease. Methods Prospective study. History, physical examination, complete blood count, serum biochemistry, abdominal ultrasound examination, and the 4 diagnostic assays for pancreatitis were performed. Intraclass correlation coefficients (ICC) were used to determine the level of agreement between each assay and a clinical suspicion score determined by a panel of 5 board-certified veterinary internists. Results The ICC between the clinical suspicion score and the 4 assays were SNAP cPL, 0.61; Spec cPL, 0.68; VetScan cPL Rapid Test, 0.68; and Precision PSL, 0.60. The sensitivities of the assays ranged from 73.9 to 100.0%, whereas the specificities were SNAP cPL, 71.1-77.8%; Spec cPL, 74.1-81.1%; VetScan cPL Rapid Test, 76.9-83.8%; and Precision PSL, 64.0-74.3%. Conclusions and clinical importance A good to excellent level of agreement was demonstrated among the 4 assays. The previously unreported sensitivity and specificity of the VetScan cPL Rapid Test were 73.9-83.3% and 76.9-83.8%, respectively. Results of any of the 4 diagnostic assays alone, in the absence of supporting clinical findings, are insufficient to establish a diagnosis of clinical pancreatitis in dogs. |
| Databáze: | OpenAIRE |
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