Antinociceptive and cytotoxic potential of ethanolic extract of Delonix regia (Leaves)

Autor:	Md. Jahir Alam, Md. Sohel Rana, Rozina Parul
Rok vydání:	2014
Předmět:	Nociception biology Traditional medicine Chemistry Cytotoxic T cell Bioassay Brine shrimp Cytotoxicity biology.organism_classification Licking Delonix regia In vitro
Zdroj:	Indian Journal of Pharmaceutical and Biological Research. 2:55-61
ISSN:	2320-9267
DOI:	10.30750/ijpbr.2.1.9
Popis:	This study investigated the antinociceptive and cytotoxic effects of alcoholic extract of Delonix regia Leaves in rodents. Antinociceptive activities were done using paw licking and writhing tests. The extract was used at dose of 200 and 400 mg/kg per orally as compared to Standard drug Diclofenac-Na 100 mg/kg bw in Swiss albino mice of body weight 25-30 g. The cytotoxic activity was determined by the Brine Shrimp lethality bioassay. The alcoholic extract showed very highly significant effect in formalin test (p less than 0.01). Also had the highest analgesia (p less than 0.001) in the acetic acid-induced writhing model as well. The extract possessed a good in vitro cytotoxic activity (LC50=4.06 µg/ml). The results suggested that Delonix regia Leaves extract has a suitable antinociceptive effect as well as cytotoxic potential.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d52c1be3c5c05bbfac6f5054d05bb6dd https://doi.org/10.30750/ijpbr.2.1.9 Zobrazit plný text záznamu