Synthesis and Biological Activity of Some Novel Aryl-Substituted 1,3,4-Oxadiazole Mannich Bases Containing Pyrimidine Rings

Autor:	Haixia Ma, Bang Chen, Shengqiang Shen, Ruyi Jin, Xiao-Hong Sun, Yuan-Fa Liu
Rok vydání:	2014
Předmět:	Antifungal Pyrimidine Stereochemistry medicine.drug_class Aryl Organic Chemistry Oxadiazole Biological activity Mannich base Ring (chemistry) chemistry.chemical_compound chemistry medicine Methyl group
Zdroj:	Journal of Heterocyclic Chemistry. 52:1296-1301
ISSN:	0022-152X
Popis:	A series of novel Mannich base derivatives (E1–E15) of 5-aryl-1,3,4-oxadiazole-2-thione with substituted pyrimidine were synthesized and characterized by elemental analysis, IR, 1H-NMR. The antifungal activities of these compounds were also originally studied. The results showed that most of the title compounds exhibited relatively good fungicidal activities. Especially compounds E8 and E13 showed better antifungal activity than comparison compound hymexazol. The relationship of structure and activity revealed that the presence of the methyl group at four and six positions of pyrimidine ring remarkably enhanced the antifungal activity of title compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d525881f001459230e38ec3c08712908 https://doi.org/10.1002/jhet.2224 Zobrazit plný text záznamu Plný text