| Popis: |
Nitroglycerin (GTN) and two of its partially denitrated analogues [1,2-dinitroglycerin (1,2-GDN) and 1,3-dinitroglycerin (1,3-GDN)] decomposed by denitration with formation of nitrate ions (N03−), but not nitrite (NO2−) ions. 1,2-GDN was converted to 1,3-GDN before denitration. The reactions occurred with first-order kinetics, and the rate constants of decomposition were higher with increases in pH and temperature. Arrhenius plots were used in the calculation of thermodynamic constants for the reactions. Activation energies for decomposition of the 3 compounds were not significantly different. The results were contrasted with those from studies of the metabolism of the same compounds, which are converted enzymatically to nitrite ions, the nitrite ions then undergoing oxidation to nitrate ions. |
