Multicomponent domino reactions in deep eutectic solvent: An efficient strategy to synthesize multisubstituted cyclohexa-1,3-dienamines
| Autor: | Najmedin Azizi, Tahereh Soleymani Ahooie, Mohammad Mahmoudi Hashemi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Green chemistry
010405 organic chemistry 010402 general chemistry Condensed Matter Physics 01 natural sciences Chloride Atomic and Molecular Physics and Optics Domino 0104 chemical sciences Electronic Optical and Magnetic Materials Deep eutectic solvent chemistry.chemical_compound chemistry Materials Chemistry medicine Organic chemistry Physical and Theoretical Chemistry Spectroscopy medicine.drug Malononitrile |
| Zdroj: | Journal of Molecular Liquids. 246:221-224 |
| ISSN: | 0167-7322 |
| DOI: | 10.1016/j.molliq.2017.09.049 |
| Popis: | The multicomponent domino reactions of ketones, aldehydes and malononitrile in a deep eutectic solvent (DES) were developed. Urea-choline chloride based DES is effective dual solvents/organocatalysts and affording a series of multisubstituted cyclohexa-1,3-dienamines in good to excellent yields under mild conditions. The DES could be easily recycled several times without appreciable loss of activity. The present protocol offers advantages in terms of environmental sustainability and efficient utilization of natural resources, operational simplicity and short reaction times. |
| Databáze: | OpenAIRE |
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