N,N-bis(trimethylsilyl)methoxymethylamine as a convenient synthetic equivalent for +CH2NH2: primary aminomethylation of esters

Autor:	Toshiaki Morimoto, Minoru Sekiya, Kohji Okano
Rok vydání:	1984
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Trimethylsilyl chemistry Silylation Yield (chemistry) Carboxylic acid Acetal Lactam Hemiaminal Molecular Medicine Ketene Organic chemistry
Zdroj:	Journal of the Chemical Society, Chemical Communications. :883
ISSN:	0022-4936
Popis:	The introduction of a primary aminomethyl unit at the α-position of esters can be achieved in high yield by the silyl trifluoromethanesulphonate-catalysed reaction of ketene silyl acetals (2) with N,N-bis(trimethylsilyl)methoxymethylamine (1).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d516b664bd8ded9055bc7e15cfc7dcd0 https://doi.org/10.1039/c39840000883 Zobrazit plný text záznamu