Effect of age and condition-test interval (days) on an audio-conditioned convulsive response in CF#1 mice

Autor: W. B. Iturrian, G. B. Fink
Rok vydání: 1968
Předmět:
Zdroj: Developmental Psychobiology. 1:230-235
ISSN: 1098-2302
0012-1630
DOI: 10.1002/dev.420010404
Popis: The initial exposure to sound provokes seizures in genetically audio-sensitive mice. In a stock (e.g., CF#1) generally considered audio-resistant, repeated sound exposure will under certain conditions induce seizure susceptibility. Susceptibility is dramatically influenced by age and interval (days) between initial and subsequent exposure to sound. Previous auditory stimulation is absolutely essential for the genesis of convulsions. Selection of age and condition-test interval produced seizures of predictable incidence and severity. Incidence in 12- or 45-day-old mice was about 5% at any interval. However, 18-day-old mice subjected to brief auditory stimulation (60 sec at 95 db) and tested at intervals of 1, 2, 3, 4, or 5 days resulted in a high incidence of convulsions. Clonic-tonic convulsions characterized the seizures at the 2- or 3-day interval; but at 5 days only clonus was seen. Without further sound stimulation mice show a transitory audio-sensitivity lasting about 5 days. Sound-induced convulsions or repeated auditory stimulation prolong sensitivity. Important characteristics of the genetically controlled audiogenic crisis in contrast with other sound-induced convulsions include: the essential prior auditory stimulation, the brief duration of susceptibility, and the adaptation to chronic noise.
Databáze: OpenAIRE
Externí odkaz: