Variations and natural history of primary intraparenchymal lesions associated with neurofibromatosis type 2

Autor: Shigeru Yamaguchi, Isao Yokota, Taisuke Harada, Michinari Okamoto, Hiroyuki Kameda, Kohsuke Kudo, Yukitomo Ishi, Shunsuke Terasaka, Miki Fujimura, Ryosuke Sawaya, Hiromi Okada, Hiroaki Motegi
Rok vydání: 2021
Předmět:
Zdroj: Neuroradiology. 64:393-396
ISSN: 1432-1920
0028-3940
DOI: 10.1007/s00234-021-02809-5
Popis: The study aimed to investigate the clinical implications and natural history of primary intraparenchymal lesions in patients with neurofibromatosis type 2. Radiological findings of 15 neurofibromatosis type 2 cases were retrospectively collected. Twenty-seven primary intraparenchymal lesions were observed in 7 out of 15 patients (47%). Cortical/subcortical T2 hyperintense lesions and enlarged Virchow–Robin spaces were the most common findings in five and four patients, respectively. During the follow-up period (median 84 months), one new primary intraparenchymal lesion was identified and increased lesions were observed in two cases on contrast-enhanced MRI. Surgical resection was performed in one case pathologically diagnosed with atypical meningioma. Twenty-five other lesions without contrast enhancement presented no apparent growth during follow-up. Although most primary intraparenchymal lesions are benign, a subset of cases would present newly developed or increased lesions on contrast-enhanced MRI. Careful monitoring is necessary for such cases, and pathological confirmation should be considered.
Databáze: OpenAIRE
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