| Autor: |
S. Kouzan, M. C. Jaurand, J. Bignon, T. Fournier, C. Voisin |
| Rok vydání: |
1989 |
| Předmět: |
|
| Zdroj: |
Effects of Mineral Dusts on Cells ISBN: 9783642742057 |
| DOI: |
10.1007/978-3-642-74203-3_28 |
| Popis: |
Exposure to Diesel exhaust can occur either in the general population or in occupationnal groups. Since a variety of mutagenic and carcinogenic substances have been identified from the gazeous and the particulate phases of Diesel exhaust, there is concern that such exposure might induce an excess of respiratory tract tumors. This concern has been substantiated by the recent finding of an increase in lung cancer risk in US (Garschik, 1987) or Canadian (Howe, 1983) railroad workers.Since pulmonary alveolar macrophage is endowed with an armamentarium with putative carcinogenic potencies, we have initiated a study assessing the effects of Diesel exhaust on alveolar macrophages. Cell reactivity was evaluated through assessment of release of arachidonic acid metabolites. In order to mimic physiological conditions, cells were cultured in gazeous phase. This enables the cells to be directly in contact with gazes. In addition, the respective role of the gazeous and the particulate phases of the Diesel exhaust were evaluated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
