Protein Complex Production from the Drug Discovery Standpoint
| Autor: | Ismail Moarefi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drug Drug discovery media_common.quotation_subject In vitro toxicology Protein engineering Computational biology Biology Pharmacology Proteomics Small molecule 03 medical and health sciences 030104 developmental biology Structure–activity relationship Function (biology) media_common |
| Zdroj: | Advanced Technologies for Protein Complex Production and Characterization ISBN: 9783319272146 |
| DOI: | 10.1007/978-3-319-27216-0_1 |
| Popis: | Small molecule drug discovery critically depends on the availability of meaningful in vitro assays to guide medicinal chemistry programs that are aimed at optimizing drug potency and selectivity. As it becomes increasingly evident, most disease relevant drug targets do not act as a single protein. In the body, they are instead generally found in complex with protein cofactors that are highly relevant for their correct function and regulation. This review highlights selected examples of the increasing trend to use biologically relevant protein complexes for rational drug discovery to reduce costly late phase attritions due to lack of efficacy or toxicity. |
| Databáze: | OpenAIRE |
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