Molecular design and targeted synthesis of N-substituted 4-oxo-1,4-dihydropyrimidine derivatives on the basis of inhibitory neurotransmitters

Autor:	I. N. Turenkov, E. T. Oganesyan, V. V. Bagmetova, A. V. Pogrebnyak, A. A. Glushko, I. P. Kodonidi, D. S. Zolotykh
Rok vydání:	2009
Předmět:	Pharmacology chemistry.chemical_classification chemistry.chemical_compound Chemistry Stereochemistry Drug Discovery Pharmacology toxicology Pharmacophore Inhibitory postsynaptic potential Neurotransmitter Receptor Amino acid
Zdroj:	Pharmaceutical Chemistry Journal. 43:568-574
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-010-0352-6
Popis:	A complex approach to the molecular design of a new class of neurotropic compounds on the basis of N-substituted 4-oxo-1,4-dihydropyrimidine is proposed. According to predictions, the 4-oxopyrimidine nucleus acts as the basic pharmacophore fragment while neurotransmitter amino acids and peptides are used as secondary pharmacophore fragments. On this basis, a set of N-substituted 4-oxo-1,4-dihydropyrimidine derivatives was synthesized. Initial pharmacological screening showed evidence for pronounced psychotropic activity of the synthesized compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d505d823c4e24223189c94e7236ca3f8 https://doi.org/10.1007/s11094-010-0352-6 Zobrazit plný text záznamu Plný text ve formátu PDF