Genome-wide screen in obese pedigrees with type 2 diabetes mellitus from a defined Dutch population
| Autor: | Cisca Wijmenga, Eric Strengman, Lodewijk A. Sandkuijl, Lude Franke, Peter L. Pearson, T.W. van Haeften, J. H. O. van Tilburg |
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| Rok vydání: | 2003 |
| Předmět: |
Genetics
medicine.medical_specialty business.industry Clinical Biochemistry Type 2 Diabetes Mellitus Pedigree chart General Medicine Type 2 diabetes Population stratification medicine.disease Biochemistry Obesity Endocrinology Internal medicine Diabetes mellitus medicine Genetic predisposition business Body mass index |
| Zdroj: | European Journal of Clinical Investigation. 33:1070-1074 |
| ISSN: | 0014-2972 |
| DOI: | 10.1111/j.1365-2362.2003.01276.x |
| Popis: | A genome scan was performed in obese type 2 diabetes mellitus pedigrees to identify susceptibility loci involved in obesity-driven type 2 diabetes mellitus. We studied the 20% most obese diabetes pedigrees from a confined Dutch population from around the town of Breda. Previously we, and others, have already shown that a susceptibility locus influencing obesity in diabetes may reside on chromosome 18p11. We now report evidence to also suggest linkage for type 2 diabetes in these obese pedigrees on chromosome regions 11p (genome-wide P-value ≤ 0·061) and 12q (genome-wide P-value ≤ 0·029), thereby confirming previous findings from corresponding regions. The linkage found in the Breda Cohort of type 2 diabetes patients is influenced by obesity. This supports the notion that a genetic predisposition to obesity is probably intertwined with a genetic predisposition to type 2 diabetes. Further efforts should address the question of how, on a genetic level, these two factors interact. |
| Databáze: | OpenAIRE |
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