Circadian rhythm of stimulated lymphocyte blastogenesis

Autor:	Vera S. Byers, H.Hugh Fudenberg, M.S. Kaplan, Lucien N. Lecam, Donald F. German, Alan S. Levin
Rok vydání:	1976
Předmět:	medicine.medical_specialty Period (gene) Immunology T cell reactivity Stimulation T lymphocyte Biology In vitro Lymphocyte blastogenesis Endocrinology Antigen Internal medicine medicine Immunology and Allergy Circadian rhythm
Zdroj:	Journal of Allergy and Clinical Immunology. 58:180-189
ISSN:	0091-6749
Popis:	The in vitro measurement of stimulated T lymphocyte blastogenesis by the incorporation of 14C-thymidine can be shown to be an acceptable and precise measurement with highly significant variations in blastogenesis over a 24 hr period. This circadian rhythm for human T lymphocyte blastogenesis has been demonstrated with specific antigen (SKSD) and in mixed leukocyte culture (MLC). The hours of peak reactivity were different for the SKSD stimulation and the MLC reaction. This biologic cycle in T cell reactivity has significant implications for the immunologic response.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d500e698f1db438a20ebcada65888460 https://doi.org/10.1016/0091-6749(76)90153-6 Zobrazit plný text záznamu