Synthesis of Spirocyclic Pyridoazepines as Analogues of Galanthamine by Nucleophilic Aromatic Substitution of 3-Substituted 2-Chloropyridines

Autor:	Sofie Vanlaer, Frans Compernolle, Wim M. De Borggraeve
Rok vydání:	2007
Předmět:	Ozonolysis Nucleophilic aromatic substitution Chemistry Stereochemistry Alkaloid Intramolecular force Organic Chemistry Organic chemistry Physical and Theoretical Chemistry
Zdroj:	European Journal of Organic Chemistry. 2007:4995-4998
ISSN:	1099-0690 1434-193X
DOI:	10.1002/ejoc.200700614
Popis:	In this report we describe the synthesis of spirocyclic pyridoazepines starting from easily available precursors. The key step of our synthesis is an intramolecular nucleophilic aromatic substitution of the appropriate 3-substituted 2-chloropyridines. The final compounds, designed as simplified analogues of the alkaloid galanthamine, showed significant acetylcholinesterase inhibition activity.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Databáze:	OpenAIRE
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