Platelet Aggregation in Vitro and Ex Vivo in Normal Pregnancy, Pregnancy-Induced Hypertension, and Preeclampsia
| Autor: | Henry Nisell, Christer Sylvén, Margareta Berglund, Charlotta Grunewald, Karl-Erik Karlberg, Nils-Olov Lunell |
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| Rok vydání: | 1998 |
| Předmět: |
Gestational hypertension
Prothrombin time medicine.medical_specialty medicine.diagnostic_test business.industry Obstetrics and Gynecology medicine.disease Preeclampsia Endocrinology Internal medicine Immunology Internal Medicine Medicine Thromboplastin Platelet Spontaneous platelet aggregation business Ex vivo Whole blood |
| Zdroj: | Hypertension in Pregnancy. 17:147-155 |
| ISSN: | 1525-6065 1064-1955 |
| Popis: | Objective: To compare women with preeclampsia, pregnancy-induced hypertension (PIH), and norrnotensive pregnant women with regard to different coagulation variables including filtragometry, reflecting the in vivo situation more closely than conventional in vitro methods.Methods: Blood was sampled for analyses of platelet count, antithrombin III (AT III) concentration, activated partial thromboplastin (APT) time, and prothrombin time in 15 patients with preeclampsia, 11 with PIH, and 13 normotensive pregnant women in the third trimester. We also applied whole blood aggregometry in vitro by the addition of 1 μg of collagen to 1 mL of diluted blood and filtragometry measuring spontaneous platelet aggregation ex vivo by estimating the time to develop a pressure gradient of 10 mm Hg over a filter occluded by platelet aggregates. The Kruskal—Wallis nonparametric test was used for statistical analyses.Results: APT time and prothrombin time did not differ among the three groups. Platelet count was normal except f... |
| Databáze: | OpenAIRE |
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