Naumovozyma castellii: an alternative model for budding yeast molecular biology
| Autor: | Ahu Karademir Andersson, Marita Cohn |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Whole genome sequencing medicine.medical_specialty Genome evolution biology ved/biology Lineage (evolution) ved/biology.organism_classification_rank.species Bioengineering biology.organism_classification Applied Microbiology and Biotechnology Biochemistry Saccharomyces Molecular biology Yeast 03 medical and health sciences 030104 developmental biology Molecular evolution Molecular genetics Genetics medicine Model organism Biotechnology |
| Zdroj: | Yeast. 34:95-109 |
| ISSN: | 0749-503X |
| DOI: | 10.1002/yea.3218 |
| Popis: | Naumovozyma castellii (Saccharomyces castellii) is a member of the budding yeast family Saccharomycetaceae. It has been extensively used as a model organism for telomere biology research and has gained an increasing interest as a budding yeast model for functional analyses owing to its amenability to genetic modifications. Due to the suitable phylogenetic distance to S. cerevisiae the whole genome sequence of N. castellii has provided unique data for comparative genomic studies, and it played a key role in the establishment of the timing of the whole genome duplication and the evolutionary events that took place in the subsequent genomic evolution of the Saccharomyces lineage. Here we summarize the historical background of its establishment as a laboratory yeast species, and the development of genetic and molecular tools and strains. We review the research performed on N. castellii, focusing on areas where it has significantly contributed to the discovery of new features of molecular biology and to the advancement of our understanding of molecular evolution. |
| Databáze: | OpenAIRE |
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