Prenatal diagnosis of the VACTERL association using routine ultrasound examination
| Autor: | Pierre Déchelotte, H. Laurichesse-Delmas, Anne Debost-Legrand, Isabelle Perthus, Denis Gallot, Didier Lémery, Christine Francannet, Carole Goumy |
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| Rok vydání: | 2015 |
| Předmět: |
0303 health sciences
Embryology Fetus medicine.medical_specialty 030219 obstetrics & reproductive medicine Routine ultrasound Obstetrics business.industry 030305 genetics & heredity Ultrasound Prenatal diagnosis Tracheoesophageal fistula General Medicine medicine.disease VACTERL association 3. Good health 03 medical and health sciences Prenatal ultrasound 0302 clinical medicine Anal atresia Pediatrics Perinatology and Child Health medicine business Developmental Biology |
| Zdroj: | Birth Defects Research Part A: Clinical and Molecular Teratology. 103:880-886 |
| ISSN: | 1542-0752 |
| DOI: | 10.1002/bdra.23346 |
| Popis: | Background The prognosis and early neonatal management of the VACTERL association depend mainly on the severity of malformations ascertained prenatally. Methods Here we reviewed the spectrum of clinical features observed in cases of VACTERL association ascertained prenatally through ultrasound examination but examined at birth and compared them with cases ascertained postnatally. Results From 1995 to 2011, a total of 19 cases of VACTERL association were observed in our center; 10 were ascertained prenatally and confirmed after birth whereas 9 were ascertained only after birth. The types and frequencies of malformations observed prenatally were as follows: renal malformations (45%), tracheoesophageal fistula (44%), cardiac malformations (20%), vertebral (13%), and limb (11%) defects. Anal atresia was never detected using routine prenatal ultrasound examination. Conclusion Further studies of fetuses with the VACTERL association are necessary to better delineate the malformations spectrum observed prenatally to improve the early recognition of the VACTERL association. Birth Defects Research (Part A) 103:880–886, 2015. © 2015 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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