Barrett's esophagus: cancer and molecular biology
| Autor: | Arashinder S. Dhaliwal, Daniel Tong, Nicholas J. Clemons, J. Mark Farrant, Benjamin J. Colleypriest, Kaushal Parikh, Mark J. Krasna, Kausilia K. Krishnadath, Kiron M. Das, Leonard P. Griffiths, E. Daniel Pirchi, Katerina Dvorak, Yu Chen, David Tosh, Michael K. Gibson, Simon Law, Manisha Bajpai, Jari Räsänen, Wayne A. Phillips |
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| Rok vydání: | 2013 |
| Předmět: |
Oncology
medicine.medical_specialty Surgical approach business.industry General Neuroscience medicine.medical_treatment Esophageal adenocarcinoma Cancer medicine.disease Molecular biology humanities digestive system diseases General Biochemistry Genetics and Molecular Biology medicine.anatomical_structure History and Philosophy of Science Esophagectomy Internal medicine Barrett's esophagus medicine Esophagus CDX2 business Chemoradiotherapy |
| Zdroj: | Annals of the New York Academy of Sciences. 1300:296-314 |
| ISSN: | 0077-8923 |
| DOI: | 10.1111/nyas.12252 |
| Popis: | The following paper on the molecular biology of Barrett's esophagus (BE) includes commentaries on signaling pathways central to the development of BE including Hh, NF-κB, and IL-6/STAT3; surgical approaches for esophagectomy and classification of lesions by appropriate therapy; the debate over the merits of minimally invasive esophagectomy versus open surgery; outcomes for patients with pharyngolaryngoesophagectomy; the applications of neoadjuvant chemotherapy and chemoradiotherapy; animal models examining the surgical models of BE and esophageal adenocarcinoma; the roles of various morphogens and Cdx2 in BE; and the use of in vitro BE models for chemoprevention studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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