Tris(2,6-dimethoxyphenyl)methyl carbenium ion as a charge derivatization agent for the analysis of primary amines by MALDI mass spectrometry

Autor:	M. S. Slyundina, A. V. Ustinov, Vladimir A. Korshun, D. A. Strizhevskaya, Roman S. Borisov, Maria A. Belyaeva, O. M. Ivanova, I. V. Mikhura, A. P. Topolyan, Andrey A. Formanovsky
Rok vydání:	2016
Předmět:	Tris Mass increment Primary (chemistry) 010401 analytical chemistry 010402 general chemistry Mass spectrometry 01 natural sciences Medicinal chemistry 0104 chemical sciences Analytical Chemistry Adduct Absorbance chemistry.chemical_compound Carbenium ion chemistry Organic chemistry Derivatization
Zdroj:	Journal of Analytical Chemistry. 71:1326-1331
ISSN:	1608-3199 1061-9348
Popis:	A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl) methyl carbenium cation reacts smoothly with primary amines, forming permanently charged adducts with the mass increment +359 Da and absorbance in the UV region. The approach was tested on a number of amines, including biologically active compounds and therapeutic agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d4ce42010382234ac9e3425d11305832 https://doi.org/10.1134/s106193481614015x Zobrazit plný text záznamu Plný text ve formátu PDF