Glabridin alleviates ischemia/reperfusion-induced functional failure of smooth muscle of rat ileum by upregulating the cAMP
| Autor: | Ali Parlar, Saliha Ayşenur Çam, Seyfullah Oktay Arslan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Modern medicine Antioxidant biology Chemistry medicine.medical_treatment Ischemia Ileum Plant Science medicine.disease biology.organism_classification Contractility chemistry.chemical_compound medicine.anatomical_structure Complementary and alternative medicine Drug Discovery medicine Glycyrrhiza Acetylcholine Glabridin medicine.drug |
| Zdroj: | Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas. 19:555-568 |
| ISSN: | 0717-7917 |
| DOI: | 10.37360/blacpma.20.19.5.39 |
| Popis: | Despite the development of modern medicine, alternative medicine, which has not lost its timeliness, remains attractive for the treatment of various diseases. Glabridin, a major flavonoid of Glycyrrhiza glabra, is known for its antioxidant and anti-inflammatory activity. The aim of this study was: 1) to determine the possible protective role of glabridin against ischemia/reperfusion (I/R) injury of the intestine; 2) to evaluate the in vitro contractile responses of ileum smooth muscles to acetylcholine after an intestinal I/R; and 3) to explain the underlying molecular mechanism of its effect. Rats were assigned to groups of six rats each; 1) I/R, 2) gla10, 3) gla20, 4) gla40, 5) N5-[imino(nitroamino)methyl]-L-ornithine, methyl ester monohydrochloride (L-NAME)+gla40, and 6) Sham group. The healing effect of glabridin was abolished by L-NAME. Glabridin did not cause contractility of the smooth muscles to acetylcholine-induced contractile responses in intestinal I/R. Yet, it increased to spontaneous basal activity. |
| Databáze: | OpenAIRE |
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