First-in-human dose-escalating trial of E.coli purine nucleoside phosphorylase and fludarabine gene therapy for advanced solid tumors

Autor:	Robert M. Conry, Paula W. Allan, Lisa Clemons, Joshua S. Richman, Eben L. Rosenthal, Kyle Mannion, Thomas K. Chung, Jeong S. Hong, Lisle Nabell, Frank R Hunt, William B. Parker, William R. Carroll, Eric J. Sorscher, Deborah Lowman
Rok vydání:	2015
Předmět:	Antitumor activity Cancer Research Regimen Oncology business.industry Genetic enhancement medicine Purine nucleoside phosphorylase First in human Pharmacology business Fludarabine medicine.drug
Zdroj:	Journal of Clinical Oncology. 33:3084-3084
ISSN:	1527-7755 0732-183X
Popis:	3084 Background: The use of E. coli purine nucleoside phosphorylase (PNP) to activate fludarabine was safe and demonstrated robust antitumor activity in preclinical studies. The regimen demonstrate...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d4c4e3b1bdfe5fc618359d10a1f9090c https://doi.org/10.1200/jco.2015.33.15_suppl.3084 Zobrazit plný text záznamu