Mucosal Protective Agent: Sucralfate in the Treatment of Gastroesophageal Reflux Disease in Children

Autor:	Marc A. Benninga, Marije J. Smits
Rok vydání:	2017
Předmět:	biology Chemistry Albumin Reflux Pharmacology Protective barrier Back diffusion Sucralfate Pepsin Sucrose octasulfate biology.protein medicine Gastric acid medicine.drug
Zdroj:	Esophageal and Gastric Disorders in Infancy and Childhood ISBN: 9783642112010
Popis:	Sucralfate is a mucosal protective coating agent that binds selectively to damaged or inflamed tissue to form a protective barrier. Sucralfate is a basic aluminum salt of sucrose octasulfate. At an acid pH, it forms large complexes with proteins (primary albumin and fibrogen) that adhere to the damaged tissue to prevent back diffusion of gastric acid, pepsin, and bile salts. Sucralfate also inhibits the direct binding of pepsin to ulcer protein and absorbs bile acids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d4bdcd3d2461e51a0a93ba9ef27c4916 https://doi.org/10.1007/978-3-642-11202-7_86 Zobrazit plný text záznamu