The Effect of Phosphorus32, Dextran, Reserpine and Stypturon on Thrombus Formation in Rats

Autor:	Jaques Lb, Ashwin Jg
Rok vydání:	1961
Předmět:	chemistry.chemical_compound Dextran Biochemistry Chemistry medicine Hematology Thrombus Reserpine Pharmacology medicine.disease Phosphorus-32 medicine.drug
Zdroj:	Thrombosis and Haemostasis. :543-552
ISSN:	2567-689X 0340-6245
DOI:	10.1055/s-0038-1654947
Popis:	SummaryThe effect of the radioisotope P32, hydrolysed dextran, reserpine, stypturon on thrombus formation was determined by injecting these substances into rats before a standardized operation on the jugular vein. 5 hours after the operation 65% of control animals showed a thrombus. 10 days after intravenous injection of 2, 3, or 4 µC/g, the incidence of thrombosis was lowered in direct relation with the reduced platelet counts varying from 65% incidence for counts above 200 000/mm3 to 0% incidence for counts less than 38 000/mm3. Animals injected with dextran, 2 hours, or reserpine, 48 hours before the operation had an incidence of thrombosis of 48% (P
Databáze:	OpenAIRE
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