Efficient access to polysubstituted tetrahydrofurans by electrophilic cyclization of vinylsilyl alcohols

Autor:	Asunción Barbero, Alberto Diez-Varga, Patricia Val, Héctor Barbero, Francisco J. Pulido, Alfonso González-Ortega, Joaquín R. Morán
Rok vydání:	2015
Předmět:	chemistry.chemical_compound chemistry Stereochemistry General Chemical Engineering Electrophile Intramolecular cyclization Stereoselectivity Alcohol General Chemistry Medicinal chemistry
Zdroj:	RSC Advances. 5:49541-49551
ISSN:	2046-2069
DOI:	10.1039/c5ra06640a
Popis:	Vinylsilyl alcohols undergo intramolecular cyclization to provide di-, tri- or tetrasubstituted-tetrahydrofurans. The influence of the number and position of substituents in the stereoselectivity of the process has been studied. Moreover, DFT calculations have been performed to get better insight into the influence of the substitution pattern of the vinylsilyl alcohol in the stereoselectivity of the cyclization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d4a2bfe33f6958e87cd65e670aa6e4ea https://doi.org/10.1039/c5ra06640a Zobrazit plný text záznamu