Specificity in hydrolysis of the A and B chains of the oxidized insulin by carboxylic resins

Autor:	S. V. Makhortych, K. M. Genender, G. V. Samsonov, V. A. Dinaburg, L. R. Gudkin, M. V. Glikina
Rok vydání:	2007
Předmět:	Chemistry Insulin medicine.medical_treatment Ionic bonding Substrate (chemistry) Cysteic acid Catalysis Matrix (chemical analysis) Hydrolysis chemistry.chemical_compound Intramolecular force Polymer chemistry medicine Organic chemistry
Zdroj:	Journal of Polymer Science Part C: Polymer Symposia. 16:2239-2250
ISSN:	1935-3065 0449-2994
DOI:	10.1002/polc.5070160437
Popis:	The catalytic activity and the specific action of nine carboxylic ion-exchange resins of various structure has been investigated on the example of a hydrolysis of two individual substrates: A and B chains of oxidized insulin. It has been shown that nearly all these catalysts hydrolyze both substrates. A specific arrangement of the catalyst matrix to a given substrate is shown to be necessary for manifesting the catalytic capacity of the resin in intramolecular catalysis. A change in the catalyst structure, in the length of the chain, and the nature of the crosslinking agent strongly influence the hydrolyzing effect and depends on the structure of substrate. Variation of the catalysis with ionic force and pH of reaction mixture has been shown. The specific action of these catalysts has been determined and it has been shown that the first bond to be hydrolyzed is the one at the C-end of cysteic acid or the next to it.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d48ff1d2517743a50a798027b413c5b3 https://doi.org/10.1002/polc.5070160437 Zobrazit plný text záznamu