Identification of bioactive compounds with GC–Q-TOF–MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction
| Autor: | Sahena Ferdosh, Hamed Mirhosseini, M.H.A. Jahurul, B. Y. Kamaruzzaman, I.S.M. Zaidul, Md. Ariful Alam, Kashif Ghafoor, Md. Eaqub Ali, Alfi Khatib |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Antioxidant Chromatography 010405 organic chemistry ved/biology Process Chemistry and Technology General Chemical Engineering medicine.medical_treatment 010401 analytical chemistry ved/biology.organism_classification_rank.species Flavonoid Extraction (chemistry) Filtration and Separation Biological activity General Chemistry Factorial experiment 01 natural sciences Clinacanthus nutans 0104 chemical sciences chemistry.chemical_compound chemistry Yield (chemistry) Carbon dioxide medicine |
| Zdroj: | Separation Science and Technology. 52:852-863 |
| ISSN: | 1520-5754 0149-6395 |
| DOI: | 10.1080/01496395.2016.1271342 |
| Popis: | Subcritical carbon dioxide Soxhlet extraction of biologically active compounds from Clincanthus nutans was investigated by full factorial design to identify and optimize the factors (particle size and co-solvent) affecting extract yield, antioxidant activity, total phenolic content, total flavonoid content, and α-glucosidase inhibitory activity. An average of 3.103% yield, 98.90% antioxidant activity, 49.40 mg/g (GAE) TPC, 43.76 mg/g (RE), and 88.58% AGI activity can be achieved using the optimum levels of independent variables. The GC-Q-TOF MS identification of optimized extract shown that different classes of phytoconstituents were successfully separated by CO2-Soxhlet to produce potential antioxidant and α-glucosidase inhibitory activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|