A concise synthesis of a benzimidazole analogue of mycophenolic acid using a BF3-Et2O catalyzed amino-claisen rearrangement

Autor:	Gaifa Lai, Wayne K. Anderson
Rok vydání:	1993
Předmět:	Benzimidazole Bicyclic molecule Stereochemistry Organic Chemistry Biochemistry Mycophenolic acid Catalysis Claisen rearrangement Acid catalysis chemistry.chemical_compound chemistry o-Phenylenediamine Drug Discovery medicine Organic chemistry Aliphatic compound medicine.drug
Zdroj:	Tetrahedron Letters. 34:6849-6852
ISSN:	0040-4039
Popis:	A nine-step synthesis of the benzimidazole analogue, 2 , of mycophenolic acid is reported involving both the BF 3 -Et 2 O catalysed aromatic amino- and the ortho ester Claisen rearrangements as key steps.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d48531725abaa5d096b921cdb1669d00 https://doi.org/10.1016/s0040-4039(00)91811-2 Zobrazit plný text záznamu